VIAGRA Info

Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer’s Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.[1][2] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.[3] It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion.

The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes.[4] Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience.

Even though sildenafil is available by prescription from a doctor, it was advertised directly to consumers on U.S. TV (famously being endorsed by former United States Senator Bob Dole and football star Pelé). Numerous sites on the Internet offer Viagra for sale after an “online consultation”, a mere web questionnaire. The “Viagra” name has become so well known that many fake aphrodisiacs now call themselves “herbal Viagra” or are presented as blue tablets imitating the shape and colour of Pfizer’s product. Viagra is also informally known as “Vitamin V”, “the Blue Pill”, as well as various other nicknames.

In February 2007, it was announced that Boots the Chemist would trial over the counter sales of Viagra in stores in Manchester, England. Men aged between 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist.[5]

Pfizer’s worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence was invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002.

The very first thing that most men do before starting the treatment of erectile dysfunction is asking their therapists which drug is the most effective… But is it that easy to answer this question?

Most probably, the ones to choose from will be the most popular of the PDE5 inhibitors: Viagra, Levitra, and Cialis. However, a real sexual health professional will most probably advise you to use Cialis – simply because its effect lasts much longer than that of its analogues (36 hours against 4-5 hours), while its side effects are pretty much same with those of any other ED meds.

Don’t be mislead by the hasty assumptions of some doctors who say that the only thing that ALL PDE5 inhibitors are capable of is comforting the patient psychologically, thus stimulating the natural sexual ability of his organism. The results of a recent research published in July 2006 in the Journal of Sexual Medicine prove exactly the opposite…

The head of the project, Dr. John Dean, and a number of other prominent British sexual health professionals studied 367 middle-aged men who were prescribed to use either Viagra or Cialis for the period of 3 months before switching to the other medication. Another 3 months later the patients were asked which of the two drugs they found more effective and would choose to stick to in future.

The results of the research showed that Cialis outdid Viagra at the rate of about 250% with 71% of the respondents deciding to stick to it and only 29% choosing Viagra. Among the most popular reasons for the decisions given in the favor of Cialis were: better firmness of the erections acquired, extended period of effectiveness and fewer time concerns resulting from it.

We don’t mean to say that Cialis is better than Viagra, since both of them are medications of exactly the same nature with not too many differences in the formula. Still, more ED patients choose to stick to Cialis for some reason – and that must already mean something!

I suffered total ED (erectile dysfunction). This went on for a number of years. Having met someone that was somewhat younger than me and interested in sex, I tried with her to no avail. I tried several more times without success. I began using Viagra with terrific results. I still suffer ED without Viagra but with 25 or 50 mg, my erections are very firm, the size seems to be much increased but that may be only due to “use”, and I ejaculate with tremendous force and volume.

I have tried 100mg from time to time but actually seem to do better with the smaller doses. I read, and tried chewing up a 25 or 50 mg dose and it really works fast—tastes terrible but does increase the speed of erection. I suffer some flushing, and some headache and stuffiness but so what? I am having great sex on a regular basis for the first time in some 10 years. - JR, Age 65