Archive for November, 2007

Which ED Medications Do People Prefer?

Friday, November 30th, 2007

The very first thing that most men do before starting the treatment of erectile dysfunction is asking their therapists which drug is the most effective… But is it that easy to answer this question?

Most probably, the ones to choose from will be the most popular of the PDE5 inhibitors: Viagra, Levitra, and Cialis. However, a real sexual health professional will most probably advise you to use Cialis – simply because its effect lasts much longer than that of its analogues (36 hours against 4-5 hours), while its side effects are pretty much same with those of any other ED meds.

Don’t be mislead by the hasty assumptions of some doctors who say that the only thing that ALL PDE5 inhibitors are capable of is comforting the patient psychologically, thus stimulating the natural sexual ability of his organism. The results of a recent research published in July 2006 in the Journal of Sexual Medicine prove exactly the opposite…

The head of the project, Dr. John Dean, and a number of other prominent British sexual health professionals studied 367 middle-aged men who were prescribed to use either Viagra or Cialis for the period of 3 months before switching to the other medication. Another 3 months later the patients were asked which of the two drugs they found more effective and would choose to stick to in future.

The results of the research showed that Cialis outdid Viagra at the rate of about 250% with 71% of the respondents deciding to stick to it and only 29% choosing Viagra. Among the most popular reasons for the decisions given in the favor of Cialis were: better firmness of the erections acquired, extended period of effectiveness and fewer time concerns resulting from it.

We don’t mean to say that Cialis is better than Viagra, since both of them are medications of exactly the same nature with not too many differences in the formula. Still, more ED patients choose to stick to Cialis for some reason – and that must already mean something!

Viagra Pre-marketing Experience

Tuesday, November 20th, 2007

VIAGRA was administered to over 3700 patients (aged 19-87 years) during clinical trials worldwide. Over 550 patients were treated for longer than one year.

In placebo-controlled clinical studies, the discontinuation rate due to adverse events for VIAGRA (2.5%) was not significantly different from placebo (2.3%). The adverse events were generally transient and mild to moderate in nature.

In trials of all designs, adverse events reported by patients receiving VIAGRA were generally similar. In fixed-dose studies, the incidence of some adverse events increased with dose. The nature of the adverse events in flexible-dose studies, which more closely reflect the recommended dosage regimen, was similar to that for fixed-dose studies.

When VIAGRA was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials, the following adverse events were reported:

Taking Viagra with Alcohol and Food

Friday, November 16th, 2007

For me the effects of Viagra are greatly diminished if taken before or with a meal. Much better on an empty stomach and no alcohol. - Bob, age 63, California

I also noticed that drinking alcohol reduced the effectiveness of the Viagra. My solution was NO alcohol before sex, and only the 25 mg dose. Works great, and no side effects noticed. - Phil, Age 60, California

I can’t eat anything at all before I take it or its effects are decreased considerably.

Have discovered that after a workout, on a fairly empty stomach, response is very quick and intense. Taken with meals really causes a lag for me. - Bob, Age 45

I get a headache but it is worth it.50 mg on empty stomach seems to work best. - Mike

Viagra will work better on an empty stomach, and keep off the alcohol. - Age 51

I used it with food both times and also had a few beers after I took it and had no problem. - Age 44, New York

I am single but have sex about once each week thanks to Viagra. Currently I take the 50 mg tab and it works for me best if taken on an empty stomach. It is mostly ineffective if taken on a full stomach. - Age 81

Viagra Stories

Sunday, November 11th, 2007

Saved My Marriage

I have been on blood pressure meds for years. I was having no problem getting hard but I would lose it right in the middle of sex. I asked one doctor about Viagra because my wife was blaming herself, saying she did not turn me on anymore, I did not find her attractive, etc. Well, the doctor said to use more direct stimulation, so I shocked him and said how much more direct can you get than a blowjob. I would go soft during a blowjob. I went to a different doctor and he asked me if I wanted to try Viagra and I said yes. I will never forget the first time I tried it. I split a 100 mg in half, went and took a shower and was anticipating sex with my wife and thinking about her and wham, I got hard! I wanted to run out and show her, but didn’t. We went to bed and soon she looked over at me and my erection, her eyes get big and she said, “Oh my God, look at how big and hard you are and I haven’t even touched you yet.” She and I both loved it. I get erections like I was 18! I last longer before I come, I am larger and very hard, and like many have said, I can repeat again soon if I want and the effects last even into the next a.m. To make a long story short, a doctor and a little blue pill saved my marriage. - Age 47, Nebraska

11-year ED Cured

I am a 27-year-old male model from NY, and I have been suffering from ED since I lost my virginity at 16. I am a very good-looking male, and I can get almost any girl I want, but I was always too afraid of the embarrassment of facing a girl after 2 minutes of sex. I was tired of pleasing my girlfriend of 4 years orally. I started noticing Viagra pills laying around my father’s house, and was very curious about how they worked! I knew they had to work if my father at the age of 53 was taking them. I snuck two of his 50-mg pills, and took them home, where they laid on my dresser for 2 weeks, because I was skeptical of it actually working. After 2 weeks I finally decided to pop one of the pills 30 minutes before sex, and I was amazed at the results! After I had my daily 2-minute orgasm, I thought “Oh No, it didn’t work” and assumed my dick would go soft a minute later as usual, But it stayed ROCK HARD literally for at least 4 hours. I kept going, and going! I was having sex like I never imagined I could. I came at least two more times that night, and it never went down! My girlfriend was blown away, and begged me to stop! I never thought I would have a girl say that to me! Viagra definitely is a miracle pill. I thought I would have to deal with ED for the rest of my life. I would recommend Viagra to anyone curious enough to try it! And hopefully we will see your positive results posted on this site with the rest of ours. - Chris, Age 27, New York

Clinical Studies

Tuesday, November 6th, 2007

In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover). VIAGRA was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo.

The effectiveness of VIAGRA was evaluated in most studies using several assessment instruments. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function - IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment. Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. The patient addressed both questions at the final visit for the last 4 weeks of the study. The possible categorical responses to these questions were (0) no attempted intercourse, (1) never or almost never, (2) a few times, (3) sometimes, (4) most times, and (5) almost always or always. Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm, desire, satisfaction with intercourse, and overall sexual satisfaction. Sexual function data were also recorded by patients in a daily diary. In addition, patients were asked a global efficacy question and an optional partner questionnaire was administered.

The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 3, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function. Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse. The titration studies, in which most patients received 100 mg, showed similar results. Figure 3 shows that regardless of the baseline levels of function, subsequent function in patients treated with VIAGRA was better than that seen in patients treated with placebo. At the same time, on-treatment function was better in treated patients who were less impaired at baseline.